Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Abstract Introduction Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest selenium trace element related protection against damage caused by stress. Objective To describe the plasma levels of and erythrocyte glutathione peroxidase activity A-T patients relate them lipid status biomarkers. Methods This cross-sectional controlled study evaluating 22 (age median, 12.2 years old) matched gender age 18 healthy controls. We evaluated: nutritional status, food intake, levels, activity, inflammation Results Adequate were observed 24/36 (66.7%) this evaluated population. There was no statistically significant difference between groups [47.6 μg/L (43.2–57.0) vs 54.6 (45.2–62.6) μg/dL, p = 0.242]. Nine (41%) had below reference value. The group presented higher LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I1, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L 2.8 µg/L, 0.029] lower Apo-A-I1/HDL-c [7300 U/L 8686 U/L, 0.005]. Selenium influenced, both groups, independently, concentrations malonaldehyde non-HDL-c. LDL (AUC 0.849) ALT 0.854) variables showed greatest discriminatory power groups. Conclusion In conclusion, we presence value nearly 40% low GPx patients. significant, inverse independent association Those data reinforce importance assessing those